Five enabling contextual factors contributed to the successful response to HIV/AIDS in Tamil Nadu:
| Strong political will and administrative commitment from the Government of Tamil Nadu | 
| 1. | Setting up and registering a State AIDS Control Society (SACS) in 1994 | |
| 2. | Introducing and scaling up Targeted Intervention (TI) program for high risk groups in partnership with Non-Government Organizations (NGOs) and Community Based Organizations (CBOs) | |
| 3. | Establishing a Transgender Welfare Board in 2008 headed by the Minister for Social Welfare | |
| 4. | Pioneering Behavioural Surveillance Survey (BSS) to track the HIV epidemic and understand behavioural changes among high risk groups, bridge population and general population | |
| 5. | Removing barriers to entering educational institutions and work places for Transgender persons | 
| Intensive multi-media behaviour change communication campaigns | |
| Identification of core high risk HIV transmitter groups | |
| Structured Targeted Intervention program focusing on high risk groups | |
| Strong treatment, care and support program | 
 
                 
                 
                 
                 
                 
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